Carnitine O-palmitoyltransferase

Choline/Carnitine o-acyltransferase
Structure of carnitine acetyltransferase.[1]
Identifiers
Symbol	Carn_acyltransf
Pfam	PF00755
Pfam clan	CL0149
InterPro	IPR000542
PROSITE	PDOC00402
SCOP	1ndi
Available protein structures: Pfam structures PDB RCSB PDB; PDBe PDBsum structure summary

Carnitine O-palmitoyltransferase (also called carnitine palmitoyltransferase) is a mitochondrial transferase enzyme (EC 2.3.1.21) involved in the metabolism of palmitoylcarnitine into palmitoyl-CoA. A related transferase is carnitine acyltransferase.

Contents 1 Molecules 2 Pathway 3 Human forms of CPT 4 See also 5 References 6 External links

Molecules

Pathway

Human forms of CPT

There are four different forms of CPT in humans:

• CPT1A - associated with Carnitine palmitoyltransferase I deficiency
• CPT1B
• CPT1C
• CPT2 - associated with Carnitine palmitoyltransferase II deficiency

See also

• Fatty_acid_degradation#Transport_into_the_mitochondrial_matrix

References

External links

• PDOC00402 - Acyltransferases ChoActase / COT / CPT family in PROSITE
• Choline/Carnitine o-acyltransferase family in Pfam
• UMich Orientation of Proteins in Membranes protein/pdbid-2h4t
• MeSH Carnitine+O-Palmitoyltransferase

Transferases: acyltransferases (EC 2.3) 2.3.1: other than amino-acyl groups acetyltransferases: Acetyl-Coenzyme A acetyltransferase - N-Acetylglutamate synthase - Choline acetyltransferase - Dihydrolipoyl transacetylase - Acetyl-CoA C-acyltransferase - Beta-galactoside transacetylase - Chloramphenicol acetyltransferase - N-acetyltransferase (Serotonin N-acetyl transferase, HGSNAT, ARD1A) - Histone acetyltransferase (P300/CBP, NAT2) palmitoyltransferases: Carnitine O-palmitoyltransferase (CPT1, CPT2) - Serine C-palmitoyltransferase (SPTLC1, SPTLC2) other: Acyltransferase like 2 - Aminolevulinic acid synthase - Beta-ketoacyl-ACP synthase - Glyceronephosphate O-acyltransferase - Lecithin-cholesterol acyltransferase Glycerol-3-phosphate O-acyltransferase - 1-acylglycerol-3-phosphate O-acyltransferase - 2-acylglycerol-3-phosphate O-acyltransferase - ABHD5 2.3.2: Aminoacyltransferases Gamma-glutamyl transpeptidase - Peptidyl transferase - Transglutaminase (Tissue transglutaminase, Keratinocyte transglutaminase, Factor XIII) 2.3.3: converted into alkyl on transfer Citrate synthase - ATP citrate lyase - HMG-CoA synthase B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6

Metabolism: lipid metabolism / fatty acid metabolism  · triglyceride and fatty acid enzymes Synthesis Malonyl-CoA synthesis ATP citrate lyase · Acetyl-CoA carboxylase Fatty acid synthesis/ Fatty acid synthase Beta-ketoacyl-ACP synthase · Β-Ketoacyl ACP reductase · 3-Hydroxyacyl ACP dehydrase · Enoyl ACP reductase Fatty acid desaturases Stearoyl-CoA_desaturase-1 Triacyl glycerol Glycerol-3-phosphate dehydrogenase · Thiokinase Degradation Acyl transport Carnitine palmitoyltransferase I · Carnitine-acylcarnitine translocase · Carnitine palmitoyltransferase II Beta oxidation General Acyl CoA dehydrogenase (ACADL, ACADM, ACADS, ACADVL, ACADSB) · Enoyl-CoA hydratase MTP: HADH · HADHA · HADHB Acetyl-CoA C-acyltransferase Unsaturated Enoyl CoA isomerase · 2,4 Dienoyl-CoA reductase Odd chain Propionyl-CoA carboxylase Other Hydroxyacyl-Coenzyme A dehydrogenase To acetyl-CoA Malonyl-CoA decarboxylase Aldehydes Long-chain-aldehyde dehydrogenase M: MET mt, k, c/g/r/p/y/i, f/h/s/l/o/e, a/u, n, m k, cgrp/y/i, f/h/s/l/o/e, au, n, m, epon m(A16/C10),i(k, c/g/r/p/y/i, f/h/s/o/e, a/u, n, m)